00:00 [Video title animates on screen.]
Mia: How to inject Omvoh.
Caption: How to inject Omvoh® (mirikizumab-mrkz)
00:04 [The narrator, Mia, walks on screen and begins speaking. She is in her kitchen.]
Mia: Hi! I’m Mia.
Caption: Hi! I’m Mia
00:08 [Mia continues to walk across her kitchen as she speaks.]
Mia: I'm taking Omvoh, just like you. Together, we’ll learn how to inject Omvoh, step by step, using the Omvoh Pen.
Caption: LEARN HOW TO INJECT WITH THE OMVOH PEN
00:15 [Camera zooms in on a note on the refrigerator.]
Mia: This video only explains how to inject the Omvoh pen. If you are using the prefilled syringe, please reference the Instructions for Use that came with the devices and abbreviated steps at omvoh.lilly.com.
Caption: THIS VIDEO ONLY EXPLAINS HOW TO INJECT THE OMVOH PEN. If you are using the prefilled syringe, please reference the Instructions for Use that came with the devices and abbreviated steps at omvoh.lilly.com.
00:28 [Camera pans to another note.]
Mia: Please see safety information throughout and safety summary below this video.
Caption: PLEASE SEE SAFETY INFORMATION THROUGHOUT AND SAFETY SUMMARY BELOW THIS VIDEO.
00:33 [Camera pans to another note]
Mia: Do not inject until you have received instructions from your healthcare provider.
Caption: DO NOT INJECT UNTIL YOU HAVE RECEIVED INSTRUCTIONS FROM YOUR HEALTHCARE PROVIDER. If you have vision or hearing problems, do not use the Omvoh Pen without help from a healthcare provider or caregiver.
00:45 [Camera pans to a photo of Mia and Manny.]
Mia: This is Manny. He's on his way here. Let's see where he's at.
Caption: This is Manny. He's on his way here. Let's see where he's at.
00:51 [Transition to Manny on a neighborhood path.]
Caption: LEARN HOW TO INJECT OMVOH STEP BY STEP
00:55 [Manny walks to the next checkpoint, and the path behind him turns blue. A clock appears above him with the minute hand turning to the half hour.]
Caption: PREPARE
1:00 [Transition back to Mia in her kitchen.]
Mia: Let's prepare to inject Omvoh!
Caption: PREPARE TO INJECT OMVOH
1:04 [Mia walks across her kitchen. Blue and green panels with dosing information slide in from opposite sides of the screen to meet in the middle.]
Mia: Omvoh is approved for treating both ulcerative colitis and Crohn’s disease. It’s important to know that the dosages for these treatments are different. For ulcerative colitis, you will use two 100mg pens. For Crohn’s disease, you will use one 100mg pen and one 200mg pen
Caption: Ulcerative Colitis FULL DOSE = Two 100mg pen injections Crohn’s Disease FULL DOSE = One 100mg and one 200mg pen injections
1:24 [Mia continues to walk across her home. A gallery wall appears behind her. The captioned information appears as framed art on her wall.]
Mia: Start by taking 2 Omvoh Pens from the refrigerator.
Caption: Take 2 Omvoh Pens from the refrigerator.
1:28 [Mia walks to the next frame on the gallery wall.]
Mia: Leave your pens (with the cap on) at room temperature before injecting. If you are taking Omvoh for Ulcerative Colitis, set them out for 30 minutes. If you are taking Omvoh for Crohn’s Disease, set them out for 45 minutes.
Caption: Leave your pens at room temperature. UC for 30 minutes. CD for 45 minutes.
01:42 [Mia walks to the next frame on the gallery wall.]
Mia: Inspect the pens and the medicine. Ensure the pens are not damaged and you have the right medicine that isn't past its expiration date.
Caption: Inspect the pens and the medicine.
01:50 [Mia walks to the next frame on the gallery wall.]
Mia:
The medicine should be clear or colorless but may be slightly yellow to slightly brown. Throw away the pens and do not use if the medicine is frozen, cloudy, discolored to an appearance other than clear, slightly yellow, or slightly brown, or has particles.
Caption: DO NOT USE THE PENS IF THE MEDICINE:
- Is frozen
- Is cloudy
- Is discolored
- Has particles
02:09 [Mia walks to the next frame on the gallery wall.]
Mia: Do not microwave the pens, run them under hot water, shake them, freeze them, or leave them in direct sunlight.
Caption: DO NOT MICROWAVE THE PENS, RUN THEM UNDER HOT WATER, SHAKE THEM, FREEZE THEM, OR LEAVE THEM IN DIRECT SUNLIGHT.
02:14 [Camera zooms in on another frame]
Mia: Please read the full instructions for use that come with your pens before injecting.
Caption: IMPORTANT: PLEASE READ THE FULL INSTRUCTIONS FOR USE THAT COME WITH YOUR PENS BEFORE INJECTING.
02:19 [Camera pans to a large frame on the wall. Mia gestures to the content that appears in the frame as she speaks.]
Mia: Next, choose your injection sites. It can be your abdomen, the back of your upper arm, or the front of your thigh. You can talk with your doctor to help choose the injection site that is best for you. If you choose your stomach, do not inject within 2 inches of your belly button. If you choose to inject in the back of your arm, you may ask another person to give the injection. If you choose to inject in the front of your thigh, inject at least 2 inches above your knee and 2 inches below your groin.
Caption: CHOOSE YOUR INJECTION SITES:
Abdomen, Back of upper arm, front of thigh
02:44 [Transition to Omvoh Pen appearing beside Mia.]
Mia: Let's get to know your Omvoh Pen.
Caption: Get to know your Omvoh Pen
02:46 [Camera zooms in on the Omvoh Pen. The parts of the pen are labeled as Mia speaks about them.]
Mia: Your pen should have a gray base cap, a clear base, a lock ring, and a blue injection button.
Caption: Omvoh Pen
Injection button, Lock ring, Medicine, Clear base, Twist-off base cap
02:53 [Transition to Manny on the neighborhood path. He walks to the next checkpoint, the path behind him turns blue. Two Omvoh pens appear along the path.]
Caption: PREPARE, INJECT
03:03 [Transition to the Omvoh Pen on a blue background.]
Mia: Remember to always wash your hands and clean your injection sites before injecting Omvoh. Let's go!
Caption: INJECT WITH YOUR OMVOH PEN IN 4 STEPS Pens can be used in any order
03:09 [Transition to a split screen. Caption appears on the left while an illustration of hands holding the Omvoh Pen appears on the right.
Mia: Step 1. Uncap the pen.
Make sure the pen is locked. When you are ready to inject, twist off the gray base cap and throw it away.
Caption: STEP 1. UNCAP THE PEN
Twist off the gray base cap and throw it away. Do not put the gray base cap back on or touch the needle.
03:27 [Transition to the second step. Caption appears on the left while an illustration of hands placing the Omvoh Pen flat against a person’s abdominal area appears on the right.]
Mia: Now let's move on to Step 2. Place and unlock.
Place and hold the clear base flat and firmly against your skin. Then, turn the lock ring to the unlock position.
Caption: STEP 2. PLACE AND UNLOCK
Place and hold the clear base flat and firmly against your skin. Then, turn the lock ring to the unlock position.
03:41 [Transition to the third step. Caption appears on the left while an illustration of a hand pressing and holding the injection button of the Omvoh pen appears on the right. A blue circle with the words 10 seconds for UC and a green circle with the words 15 seconds for CD appear.]
Mia: Step 3. Press and hold for up to 15 seconds.
Press and hold the blue injection button. For Ulcerative Colitis you will hold for 10 seconds and for Crohn’s Disease you will hold for 15 seconds. Listen for the first click, it means the injection has started. Keep pressing and holding the clear base firmly against the skin. When you hear the second click, that means you're done! You'll also know the injection is complete when the gray plunger is visible.
Caption: STEP 3. PRESS AND HOLD FOR UP TO 15 SECONDS
Press and hold the blue injection button. First click means the injection has started. Second click means you’re done!
04:11 [Caption appears on the left. The Omvoh Pen appears on the right.]
Mia: This injection is complete, and you can remove the pen from your skin.
Caption: THIS INJECTION IS COMPLETE. Remove the pen from your skin.
04:15 [Caption appears on the left. The two Omvoh Pens appear on the right with a spinning repeat icon above.]
Mia: Step 4. Repeat steps 1 through 3. Now that we've gone over the injection steps, it's time to repeat them for your second injection.
Caption: STEP 4. REPEAT STEPS 1-3
After first injection, immediately inject the second pen.
04:21 [Mia walks onto the left side of the screen. The caption appears on the right.]
Mia: For your second injection, make sure to rotate your injection site. Do not inject in the same spot. Let’s check on Manny.
Caption: For your second injection, make sure to rotate your injection site.
For example, if your first injection was in your abdomen, your second injection should be in another spot in your abdomen, or your upper arm or front of thigh.
04:33 [Transition to Manny on the neighborhood path. He walks to the next checkpoint, and the path behind him turns blue. A sharps container appears along the path.]
Caption: INJECT, DISPOSE
04:41 [Transition to Mia’s kitchen.]
Mia: Now let's go over how to safely dispose of Omvoh.
04:43 [Camera pans to Mia’s sharps container.]
Mia: Here's where I like to keep my sharps container.
04:49 [Camera zooms in on the sharps container.]
Mia: Dispose of your used Omvoh Pens in a sharps container and never in your household trash.
Caption: DISPOSE OF YOUR USED OMVOH PENS IN AN FDA-CLEARED SHARPS CONTAINER.
04:56 [Caption changes.]
Mia: Do not reuse the pens.
Caption: DO NOT reuse them.
04:58 [Caption changes.]
Mia: If you don't have a sharps container, you can reuse a heavy-duty plastic household container, like a laundry detergent bottle. Just make sure it's labeled, has a closable lid, and is puncture- and leak-resistant. Please follow your community guidelines for more guidance on how to dispose of your sharps container.
Caption:
- Heavy-duty plastic
- Labeled as sharps container
- Closable lid
- Puncture-resistant
- Leak-resistant
05:18 [Caption changes.]
Mia: Store away from children and do not recycle your used sharps container.
Caption: Store away from children and DO NOT recycle your used sharps container.
05:22 [Camera zooms out to show Mia on screen.]
Mia: To learn more about safe sharps disposal, visit the FDA’s website. Oh, Manny's almost here.
Caption: To learn more about safe sharps disposal, visit www.fda.gov/safesharpsdisposal.
05:29 [Transition to Manny completing the neighborhood path and arriving at Mia’s house. He walks up the stairs and knocks on the front door.]
Caption: LEARN HOW TO INJECT OMVOH STEP BY STEP
Omvoh®(mirikizumab-mrkz)
05:38 [Transition to Mia walking across her home. A speech bubble appears next to Mia.]
Mia: Got questions about Omvoh? Talk to your doctor or visit omvoh.lilly.com.
Caption: Got questions about Omvoh? Talk to your doctor or visit omvoh.lilly.com.
05:46 [Caption in speech bubble changes as Mia continues to walk.]
Mia: For more help, Lilly Support Services is here for you. Call 1-800-LillyRx (1-800-545-5979).
Caption: Lilly Support Services™ Call 1-800-Lilly-Rx (1-800-545-5979)
05:52 [Mia stops at her front door and opens it. Manny appears and waves.]
Mia: You're ready to inject with the Omvoh Pen.
05:54 [Speech bubble appears between Mia and Manny.]
Mia: Stay tuned for safety information about Omvoh.
Caption: Stay tuned for safety information
06:01 [The screen turns light blue and the Omvoh logo appears.]
AI VO: Omvoh is a prescription medicine used to treat adults with moderate to severe ulcerative colitis and adults with moderate to severe Crohn's disease
Caption: Omvoh®(mirikizumab-mrkz) A Lilly Medicine Omvoh is a prescription medicine used to treat adults with moderate to severe ulcerative colitis and adults with moderate to severe Crohn's disease. BY PRESCRIPTION ONLY.
06:11 [Safety language appears on screen. Mia’s home decor, a fish bowl and a plant, are in the background.]
AI VO and Caption:
INDICATIONS AND SAFETY SUMMARY
Omvoh® (ahm-VOH) is a medicine used to treat
- adults with moderately to severely active ulcerative colitis
- adults with moderately to severely active Crohn’s disease
It is not known if Omvoh is safe and effective in children under 18 years of age.
Warnings – Omvoh can cause serious side effects including:
Serious allergic reactions: Omvoh may cause serious allergic reactions that may need to be treated in a hospital and may be life-threatening. Do not use Omvoh if you have had a serious allergic reaction to mirikizumab-mrkz or any of the ingredients in Omvoh. See the Medication Guide that comes with Omvoh for a list of ingredients. Stop using Omvoh and get emergency medical help right away if you develop any of the following symptoms of a serious allergic reaction:
- fainting, dizziness, feeling lightheaded
- swelling of your face, eyelids, lips, mouth, tongue, throat, or trouble swallowing
- trouble breathing, throat tightening, or wheezing
- chest tightness
- fast heartbeat or pounding in your chest
- severe itching, hives, or redness all over your body
- sweating
Infections: Omvoh may lower the ability of your immune system to fight infections and may increase your risk of infections. If you have an infection, your healthcare provider should not start treatment with Omvoh until your infection is gone. Before starting treatment with Omvoh, your healthcare provider should assess you for tuberculosis (TB). If you are at risk for TB, you may be treated with medicine for TB before you begin treatment with Omvoh. Your healthcare provider should watch you closely for signs and symptoms of TB while you are being treated with Omvoh and after treatment.
Before starting Omvoh, tell your healthcare provider if you think you have an infection or have symptoms of an infection, such as:
- fever, sweating, or chills
- muscle aches and pain
- cough or shortness of breath
- blood in your mucus (phlegm)
- flu-like symptoms
- headache
- warm, red, or painful skin or sores on your body
- diarrhea or stomach pain
- weight loss
- nausea or vomiting
- pain during urination
After starting Omvoh, tell your healthcare provider right away if you have any symptoms of an infection.
Liver Problems: Omvoh may cause liver problems. Your healthcare provider should do blood tests to check your liver enzyme and bilirubin levels before treatment, during, and after treatment with Omvoh. Your healthcare provider may hold or stop treatment if needed. Tell your healthcare provider right away if you develop any signs and symptoms of liver problems, including
- unexplained rash
- nausea
- vomiting
- stomach-area (abdominal) pain
- feeling tired
- loss of appetite
- yellowing of the skin or the whites of your eyes
- dark urine
Common side effects
The most common side effects of Omvoh in people treated for ulcerative colitis include:
- upper respiratory infections
- injection site reaction
- joint pain
- rash
- headache
- herpes viral infections
The most common side effects of Omvoh in people treated for Crohn’s disease include:
- upper respiratory infections
- injection site reactions
- headache
- joint pain
- elevated liver blood tests
These are not all the possible side effects of Omvoh.
Tell your doctor if you have any side effects. You can report side effects at 1-800-FDA-1088 or www.fda.gov/medwatch.
Before you use Omvoh, review these questions with your doctor:
- Are you being treated for an infection?
- Do you have an infection that does not go away or keeps coming back?
- Do you have TB or have you been in close contact with someone with TB?
- Do you have any possible symptoms of an infection such as fever, chills, muscle aches, cough, shortness of breath, runny nose, sore throat, or pain during urination?
Tell your doctor about all your medical conditions, including if:
- You have a history of serious allergic reaction to Omvoh, any infections or liver problems.
- You need any vaccines or have had one recently. Medicines that interact with the immune system may increase your risk of getting an infection after receiving live vaccines. You should avoid receiving live vaccines right before, during or right after treatment with Omvoh. Tell your healthcare provider that you are taking Omvoh before receiving a vaccine.
- You are pregnant, or plan to become pregnant. It is not known if Omvoh will harm your unborn baby. There will be a pregnancy registry to collect information about women who are exposed to Omvoh during pregnancy. If you become pregnant while taking Omvoh, you are encouraged to report your pregnancy to Eli Lilly and Company at 1-800-545-5979.
- You are breastfeeding or plan to breastfeed. It is not known if Omvoh passes into your breastmilk.
- You take prescription or over-the-counter medicines, vitamins, or herbal supplements.
How to take
Follow your healthcare provider’s instructions for using Omvoh. You will receive your first 3 doses of Omvoh through a vein in your arm (intravenous infusion) in a healthcare facility by a healthcare provider every 4 weeks. Each infusion will last about 30 minutes (for ulcerative colitis) or about 90 minutes (for Crohn’s disease). After induction, you will continue to receive Omvoh maintenance doses as self-injections under the skin (subcutaneous injection) every 4 weeks. For these injections, Omvoh is available as prefilled pens or prefilled syringes. For a full dose you will need two injections with either two prefilled pens or two prefilled syringes. Inject 1 Omvoh prefilled pen or prefilled syringe followed right away by the other Omvoh prefilled pen or prefilled syringe. If you give injections at home, you should be trained on the correct way to prepare and inject Omvoh. Do not try to inject Omvoh yourself until you or your caregiver have been shown how to inject. Read the detailed Instructions for Use about how to use and dispose of Omvoh the correct way.
Learn more
Omvoh is a prescription medicine. During induction, Omvoh is available as a single-dose vial for intravenous infusion containing 300 mg/15 mL that is administered in a healthcare facility.
During maintenance, Omvoh is available as:
- For ulcerative colitis: two 100 mg/mL prefilled pens or prefilled syringes.
- For Crohn’s disease: one 100 mg/mL prefilled pen or prefilled syringe and one 200 mg/2 mL prefilled pen or prefilled syringe.
For more information, call 1-800-545-5979 or go to omvoh.lilly.com.
This summary provides basic information about Omvoh but does not include all information known about this medicine. Read the information that comes with your prescription each time your prescription is filled. This information does not take the place of talking with your doctor. Be sure to talk to your doctor or other healthcare provider about Omvoh and how to take it. Your doctor is the best person to help you decide if Omvoh is right for you.
MR CON BS CD APP
Omvoh® and its delivery device base are trademarks owned or licensed by Eli Lilly and Company, its subsidiaries, or affiliates.
Voiceover audio created using AI
13:58 [End frame with Omvoh logo.]
Caption: Ask your doctor about Omvoh® (mirikizumab-mrkz) A Lilly Medicine Omvoh® and its delivery device base are trademarks owned or licensed by Eli Lilly and Company, its subsidiaries, or affiliates. Lilly Support Services™is a trademark owned by Eli Lilly and Company.
PP-MR-US-0712 01/2025 © Lilly USA, LLC, 2025. All rights reserved.
14:11 [Lilly AMC Red Logo appears]
